Joint Associations of Actual Age and Genetically Determined Age at Menarche With Risk of Mortality
نویسندگان
چکیده
منابع مشابه
Height, age at menarche, and risk of epithelial ovarian cancer.
OBJECTIVE We hypothesized that the hormonal changes of adolescence influence ovarian cancer risk particularly in younger women. We investigated this possibility by examining the relationship between ovarian cancer and adult height and age at menarche as both factors reflect pubertal hormonal levels. METHODS Participants were a population-based sample of women with incident ovarian cancer (n=7...
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We examined associations of age at menarche and menstrual characteristics with the risk of preeclampsia among participants (n = 3,365) of a pregnancy cohort study. Data were collected using in-person interviews and medical record abstraction. Logistic regression was used to estimate adjusted odds ratio (OR) and 95% confidence interval (95% CI). There was a significant inverse association betwee...
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OBJECTIVE Younger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 d...
متن کاملSize at birth predicts age at menarche.
OBJECTIVE This study examines the relationship of intrauterine growth, measured by size and maturity at birth, to age at menarche, while also considering a wide range of other factors that may affect maturation. The research is motivated by the current debate about the importance of the prenatal environment as a determinant of later disease risk. METHODS Data were collected during the Cebu Lo...
متن کاملSerum Dioxin Concentrations and Age at Menarche
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is associated with delays in pubertal development in animal studies. On 10 July 1976, as a result of a chemical explosion, residents of Seveso, Italy, experienced the highest levels of TCDD exposure experienced by a human population. Twenty years later, we initiated the Seveso Women's Health Study (SWHS), a retr...
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ژورنال
عنوان ژورنال: JAMA Network Open
سال: 2021
ISSN: 2574-3805
DOI: 10.1001/jamanetworkopen.2021.15297